Magnetic conjugated polymer nanoparticles doped with a europium complex for biomedical imaging

Photochem Photobiol Sci. 2018 Jun 13;17(6):718-721. doi: 10.1039/c7pp00402h.

Abstract

Self-assembling conjugated polymer nanoparticles containing PVK and PLGA-PEG as a matrix polymer were doped with both a luminescent rare-earth complex and magnetic nanoparticles (SPIONs), giving rise to materials that are both luminescent and magnetic. Nanoparticle sizes ranged from 80-110 nm without SPIONs and showed an increase in size (200-1000 nm) with additional SPION content (11-54%). Quantum yields (QYs) of 24% and 18% were measured for systems without and with 11% SPIONs, respectively. Optical properties were stable and suitable for biological imaging applications.

MeSH terms

  • Biomedical Research
  • Cells, Cultured
  • Europium / chemistry*
  • Humans
  • Hydrodynamics
  • Magnetite Nanoparticles / chemistry*
  • Microscopy, Confocal
  • Optical Imaging*
  • Particle Size
  • Polyesters / chemistry*
  • Polyethylene Glycols / chemistry*
  • Quantum Theory
  • Surface Properties
  • T-Lymphocytes / cytology

Substances

  • Magnetite Nanoparticles
  • Polyesters
  • polyethylene glycol-poly(lactide-co-glycolide)
  • Polyethylene Glycols
  • Europium