Modeling Mammalian Gastrulation With Embryonic Stem Cells

Eric D Siggia; Aryeh Warmflash

doi:10.1016/bs.ctdb.2018.03.001

Modeling Mammalian Gastrulation With Embryonic Stem Cells

Curr Top Dev Biol. 2018:129:1-23. doi: 10.1016/bs.ctdb.2018.03.001. Epub 2018 Apr 12.

Authors

Eric D Siggia¹, Aryeh Warmflash²

Affiliations

¹ Center for Studies in Physics and Biology, The Rockefeller University, New York, NY, United States. Electronic address: siggiae@rockefeller.edu.
² Departments of Biosciences and Bioengineering, Rice University, Houston, TX, United States. Electronic address: aryeh.warmflash@rice.edu.

Abstract

Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and molecular processes that shape the embryo. Here we review recent developments in using ESCs to create both two- and three-dimensional culture models that shed light on mammalian gastrulation.

Keywords: BMP; Embryonic stem cells; Gastrulation; Gastruloid; Micropatterning; Morphogen; Nodal; Self-organization; Turing pattern; Wnt.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Body Patterning
Cell Lineage
Embryonic Stem Cells / cytology*
Gastrulation*
Mammals / embryology*
Models, Biological*

Grants and funding

R01 GM126122/GM/NIGMS NIH HHS/United States