Activation of the p53 pathway with digiferrol isolated from Rubia philippinensis induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells

MeSH terms

• Anthraquinones / chemistry
• Anthraquinones / pharmacology*
• Antineoplastic Agents, Phytogenic / pharmacology
• Apoptosis / drug effects*
• Autophagy / drug effects*
• Cell Cycle Checkpoints / drug effects*
• Colorectal Neoplasms / metabolism*
• Gene Expression Regulation, Neoplastic / drug effects
• HCT116 Cells
• Humans
• Molecular Structure
• Rubia / chemistry*
• Tumor Suppressor Protein p53 / genetics
• Tumor Suppressor Protein p53 / metabolism