Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery

Circulation. 2018 May 29;137(22):2315-2317. doi: 10.1161/CIRCULATIONAHA.117.028194.

Authors

James W Wisler¹, Howard A Rockman^{1

2

3}, Robert J Lefkowitz^{4

5

6}

Affiliations

¹ Department of Medicine (J.W.W., H.A.R., R.J.L.).
² Department of Cell Biology (H.A.R.).
³ Department of Molecular Genetics (H.A.R.).
⁴ Department of Medicine (J.W.W., H.A.R., R.J.L.) lefko001@receptor-biol.duke.edu.
⁵ Department of Biochemistry (R.J.L.).
⁶ Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, NC.

No abstract available

Keywords: GTP-binding proteins; cardiovascular agents; heart failure; ligands; receptor, angiotensin, type 1; receptors, adrenergic.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Allosteric Regulation
Cardiovascular Diseases / metabolism
Cardiovascular Diseases / pathology
Drug Discovery*
Humans
Ligands
Receptors, G-Protein-Coupled / agonists
Receptors, G-Protein-Coupled / antagonists & inhibitors
Receptors, G-Protein-Coupled / metabolism*
Signal Transduction
beta-Arrestins / metabolism

Substances

Ligands
Receptors, G-Protein-Coupled
beta-Arrestins

Grants and funding