MUC5AC Levels Associated With Respiratory Syncytial Virus Disease Severity

Clin Infect Dis. 2018 Oct 15;67(9):1441-1444. doi: 10.1093/cid/ciy340.

Abstract

To assess MUC5AC as a biomarker for respiratory syncytial virus (RSV) disease severity, we tested nasal aspirates from RSV+ children with mild, moderate, and severe disease. Levels were significantly higher in those in the severe and moderate groups compared to mild group, indicating MUC5AC may be a useful biomarker for RSV disease severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Argentina
  • Biomarkers / analysis
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Mucin 5AC / analysis*
  • Nose / virology
  • ROC Curve
  • Respiratory Syncytial Virus Infections / complications
  • Respiratory Syncytial Virus Infections / diagnosis*
  • Respiratory Syncytial Virus, Human / genetics
  • Respiratory Syncytial Virus, Human / isolation & purification*
  • Severity of Illness Index*

Substances

  • Biomarkers
  • MUC5AC protein, human
  • Mucin 5AC