Vichy Thermal Spring Water (VTSW), a cosmetic ingredient of potential interest in the frame of skin ageing exposome: an in vitro study

Abstract

Objective: To study the effects of the very high minerality Vichy Thermal Spring Water (VTSW) on human keratinocytes grown in vitro.

Methods: The effect of VTSW was monitored by full genome transcriptomic technology and immunofluorescence microscopy.

Results: In the presence of 50% VTSW, the expression of a number of skin homoeostasis-related genes is increased, specifically with respect to dermal-epidermal junction, epidermal cohesion and communication, keratinocyte proliferation-differentiation balance, antioxidant mechanisms and DNA repair.

Conclusion: This work suggests that VTSW could be considered as an ingredient of potential interest to address some of the deleterious effects of skin ageing exposome.

Keywords: Thermal Spring Water; exposome; keratinocyte; oxidative stress; skin ageing; transcriptomics.