Microevolution and Patterns of Transmission of Shigella sonnei within Cyclic Outbreaks Shigellosis, Israel

Emerg Infect Dis. 2018 Jul;24(7):1335-1339. doi: 10.3201/eid2407.171313.

Abstract

Whole-genome sequencing unveiled host and environment-related insights to Shigella sonnei transmission within cyclic epidemics during 2000-2012 in Israel. The Israeli reservoir contains isolates belonging to S. sonnei lineage III but of different origin, shows loss of tetracycline resistance genes, and little genetic variation within the O antigen: highly relevant for Shigella vaccine development.

Keywords: Bedouin; Beer Sheva; Israel; Israeli Arabs; Mevaseret; Shigella sonnei; Whole-genome sequencing; Zion; children; flexneri; microevolution; migration; overcrowding; person-to-person transmission; secular Jews; shigellosis; tetracycline; ultraorthodox Jews.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disease Outbreaks*
  • Dysentery, Bacillary / epidemiology*
  • Dysentery, Bacillary / microbiology
  • Dysentery, Bacillary / transmission*
  • Evolution, Molecular*
  • Genome, Bacterial
  • Humans
  • Israel / epidemiology
  • Public Health Surveillance
  • Shigella sonnei / classification
  • Shigella sonnei / genetics*
  • Whole Genome Sequencing