Testing Hippocampal Memory in Prodromal Dementia with Lewy Bodies

Cinzia Bussè; Paolo Caffarra; Alice Rossi; Giovanni Zorzi; Federica Fragiacomo; Giulia Camporese; Sara Pompanin; Gian Antonio Di Bernardo; Annachiara Cagnin

doi:10.3233/JAD-180166

Testing Hippocampal Memory in Prodromal Dementia with Lewy Bodies

J Alzheimers Dis. 2018;64(2):349-353. doi: 10.3233/JAD-180166.

Authors

Affiliations

¹ Department of Neurosciences (DNS), University of Padua, Padua, Italy.
² Department of Neurosciences, Psychology, Pharmacology and Child Health, NEUROFARBA, University of Florence, Florence, Italy.
³ Section of Neuroscience, DIMEC, University of Parma, Italy.
⁴ Alzheimer Center, FERB ONLUS, Gazzaniga, Bergamo, Italy.
⁵ Department of Education and Humanities, University of Modena and Reggio Emilia, Reggio Emilia, Italy.

PMID: 29914032
DOI: 10.3233/JAD-180166

Abstract

The Free and Cued Selective Reminding test (FCSRT) was used to assess memory in 19 patients with prodromal dementia with Lewy bodies (DLB) and 25 Alzheimer's disease (AD) patients. DLB scored better than AD in selective measures of the FCSRT: immediate total recall (p = 0.01) and index of sensitivity of cueing (p = 0.001), while free delayed and total memory scores were similarly impaired. The index of sensitivity of cueing held a sensitivity of 76% and specificity of 79% in distinguishing DLB. FCSRT could help in disentangling hippocampal memory deficits from memory impairment due to ineffective recall strategies.

Keywords: Alzheimer’s disease; dementia with Lewy bodies; hippocampus; memory.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Alzheimer Disease / complications*
Cognition Disorders / diagnosis
Cognition Disorders / etiology
Cues
Female
Hippocampus / physiopathology*
Humans
Lewy Body Disease / complications*
Male
Memory Disorders / diagnosis*
Memory Disorders / etiology*
Middle Aged
Neuropsychological Tests
Prodromal Symptoms*
Psychiatric Status Rating Scales
Semantics