The ocular prosthesis is a modality of facial prosthesis that acts on the repair of loss or deformity of the ocular globe. Prosthetic rehabilitations destined to anophthalmic cavities that suffered cicatricial retraction represent a challenge during fabrication since they often need to be reduced due to atrophic of the cavity and simultaneously need to have a good esthetic appearance regarding the contour and artificial iris. This clinical report describes the ocular prosthetic rehabilitation of a 77-year-old man with anophthalmic atrophic cavity due to herpes zoster-induced loss. The treatment focused on comfort and adaptation during use, on satisfactory retention and esthetic appearance, and on care to achieve total eye closure while wearing the ocular prosthesis. This article shows an unusual prosthetic rehabilitation of atrophic anophthalmic cavity with 6 months of follow-up.