Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

Qin Zhang; Dennis K Jeppesen; James N Higginbotham; Michelle Demory Beckler; Emily J Poulin; Alex J Walsh; Melissa C Skala; Eliot T McKinley; H Charles Manning; Matthew R Hight; Michael L Schulte; Kimberly R Watt; G Daniel Ayers; Melissa M Wolf; Gabriela Andrejeva; Jeffrey C Rathmell; Jeffrey L Franklin; Robert J Coffey

doi:10.1016/j.jcmgh.2018.01.013

Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells

Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):627-629.e6. doi: 10.1016/j.jcmgh.2018.01.013. eCollection 2018.

Authors

Qin Zhang¹, Dennis K Jeppesen¹, James N Higginbotham¹, Michelle Demory Beckler^{1

2}, Emily J Poulin³, Alex J Walsh^{4

5}, Melissa C Skala^{4

5}, Eliot T McKinley¹, H Charles Manning^{2

4

6}, Matthew R Hight^{6

7}, Michael L Schulte^{2

6}, Kimberly R Watt^{1

8}, G Daniel Ayers⁹, Melissa M Wolf^{10

11}, Gabriela Andrejeva^{10

11}, Jeffrey C Rathmell^{10

11

12}, Jeffrey L Franklin^{1

3

8

13}, Robert J Coffey^{1

3

13}

Affiliations

¹ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
² Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee.
³ Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee.
⁴ Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, Tennessee.
⁵ Morgridge Institute for Research, University of Wisconsin, Madison, Wisconsin.
⁶ Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee.
⁷ Department of Physics and Astronomy, Vanderbilt University Medical Center, Nashville, Tennessee.
⁸ Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, Tennessee.
⁹ Biostatistics Center, Vanderbilt University Medical Center, Nashville, Tennessee.
¹⁰ Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
¹¹ Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee.
¹² Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee.
¹³ Department of Veterans Affairs Medical Center, Nashville, Tennessee.

No abstract available

Keywords: 18F-FSPG, (S)-4-(3-[18F]-fluoropropyl)-L-glutamic acid; Apc, adenomatous polyposis coli; CRC, colorectal cancer; DLD-1, Daniel L. Dexter derived 1; FAD, flavin adenine dinucleotide; GLUT-1, glucose transporter 1; KO, knockout; KRAS, Kirsten rat sarcoma viral oncogene homolog; NADH, Nicotinamide adenine dinucleotide reduced; WT, wild-type.

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