Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation

Yongsheng Li; Daniel J McGrail; Juan Xu; Gordon B Mills; Nidhi Sahni; Song Yi

doi:10.1016/j.tibs.2018.05.002

Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation

Trends Biochem Sci. 2018 Aug;43(8):576-592. doi: 10.1016/j.tibs.2018.05.002. Epub 2018 Jun 22.

Authors

Yongsheng Li¹, Daniel J McGrail², Juan Xu³, Gordon B Mills², Nidhi Sahni⁴, Song Yi⁵

Affiliations

¹ Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; College of Bioinformatics Science and Technology and Bio-Pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, China.
² Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
³ College of Bioinformatics Science and Technology and Bio-Pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, China.
⁴ Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Program in Quantitative and Computational Biosciences (QCB), Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA. Electronic address: nsahni@mdanderson.org.
⁵ Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA; Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: stephen.yi@austin.utexas.edu.

Abstract

Gene regulatory networks underlie biological function and cellular physiology. Alternative splicing (AS) is a fundamental step in gene regulatory networks and plays a key role in development and disease. In addition to the identification of aberrant AS events, an increasing number of studies are focusing on molecular determinants of AS, including genetic and epigenetic regulators. We review here recent efforts to identify various deregulated AS events as well as their molecular determinants that alter biological functions, and discuss clinical features of AS and their druggable potential.

Keywords: alternative splicing; computational and experimental methods; gene regulatory networks; genetic and epigenetic; molecular regulators.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Alternative Splicing
Epigenesis, Genetic*
Gene Regulatory Networks*
Genetic Variation*
High-Throughput Nucleotide Sequencing / methods
Humans

Abstract

Publication types

MeSH terms

Grants and funding