Polycomb repressive complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia

Jonathan Bond; Elise Labis; Alice Marceau-Renaut; Nicolas Duployez; Myriam Labopin; Guillaume Hypolite; Gérard Michel; Stéphane Ducassou; Hélène Boutroux; Brigitte Nelken; Yves Bertrand; André Baruchel; Arnaud Petit; Vahid Asnafi; Guy Leverger; Claude Preudhomme; Elizabeth Macintyre; Hélène Lapillonne

doi:10.1038/s41375-018-0187-9

Polycomb repressive complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia

Leukemia. 2018 Aug;32(8):1878-1882. doi: 10.1038/s41375-018-0187-9. Epub 2018 Jun 27.

Authors

Jonathan Bond^{1

2

3}, Elise Labis^{4

5}, Alice Marceau-Renaut^{5

6}, Nicolas Duployez^{5

6}, Myriam Labopin^{7

8

9

10}, Guillaume Hypolite^{11

12}, Gérard Michel¹³, Stéphane Ducassou¹⁴, Hélène Boutroux¹⁵, Brigitte Nelken¹⁶, Yves Bertrand¹⁷, André Baruchel¹⁸, Arnaud Petit¹⁵, Vahid Asnafi^{11

12}, Guy Leverger¹⁵, Claude Preudhomme^{5

6}, Elizabeth Macintyre^{11

12}, Hélène Lapillonne^{19

20

21}

Affiliations

¹ Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France. jonathan.bond@ucd.ie.
² Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France. jonathan.bond@ucd.ie.
³ School of Medicine and Systems Biology Ireland, University College Dublin, Dublin 4, Ireland. jonathan.bond@ucd.ie.
⁴ Medical Genetics Institute, Jeanne de Flandre Hospital, Centre Hospitalier Universitaire (CHU), Lille, France.
⁵ Cancer Research Institute, INSERM Unité Mixte de Recherche (UMR)-S 1172, F-59000, Lille, France.
⁶ CHU Lille, Laboratory of Hematology, F-59000, Lille, France.
⁷ Clinical Haematology and Cellular Therapy Department, Hospital Saint-Antoine, APHP, Paris, France.
⁸ EBMT ALWP Office, Hôpital Saint-Antoine, APHP, Paris, France.
⁹ Universite Pierre et Marie Curie Univ Paris 06, Paris, France.
¹⁰ INSERM UMRs 938, CDR Saint-Antoine, F-75012, Paris, France.
¹¹ Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, Paris, France.
¹² Laboratory of Onco-Haematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.
¹³ Department of Pediatric Haematology, University Hospital of La Timone, Marseille, France.
¹⁴ Department of Pediatric Hematology and Oncology, Children's Hospital, Bordeaux, France.
¹⁵ Department of Pediatric Haematology and Oncology, Hôpital Armand Trousseau, AP-HP, Paris, France.
¹⁶ Department of Pediatric Hematology-Oncology, Jeanne de Flandre Hospital, CHRU, Lille, France.
¹⁷ Institute of Pediatric Haematology and Oncology, Hospices Civils de Lyon, Lyon, France.
¹⁸ Department of Pediatric Hematology and Immunology, AP-HP, Robert Debré Hospital, Paris, France.
¹⁹ Universite Pierre et Marie Curie Univ Paris 06, Paris, France. helene.lapillonne@trs.aphp.fr.
²⁰ INSERM UMRs 938, CDR Saint-Antoine, F-75012, Paris, France. helene.lapillonne@trs.aphp.fr.
²¹ Haematology Laboratory, Hôpital Armand Trousseau, AP-HP, Paris, France. helene.lapillonne@trs.aphp.fr.

PMID: 29950694
DOI: 10.1038/s41375-018-0187-9

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / genetics*
Child
Haploinsufficiency*
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology*
Polycomb Repressive Complex 2 / genetics*
Prognosis
Risk Factors
Survival Rate

Substances

Biomarkers, Tumor
Polycomb Repressive Complex 2