The Effect of Noninvasive High-Frequency Oscillatory Ventilation on Desaturations and Bradycardia in Very Preterm Infants: A Randomized Crossover Trial

Christoph M Rüegger; Laila Lorenz; C Omar F Kamlin; Brett J Manley; Louise S Owen; Dirk Bassler; David G Tingay; Susan M Donath; Peter G Davis

doi:10.1016/j.jpeds.2018.05.029

The Effect of Noninvasive High-Frequency Oscillatory Ventilation on Desaturations and Bradycardia in Very Preterm Infants: A Randomized Crossover Trial

J Pediatr. 2018 Oct:201:269-273.e2. doi: 10.1016/j.jpeds.2018.05.029. Epub 2018 Jun 25.

Authors

Christoph M Rüegger¹, Laila Lorenz², C Omar F Kamlin³, Brett J Manley³, Louise S Owen³, Dirk Bassler⁴, David G Tingay⁵, Susan M Donath⁶, Peter G Davis³

Affiliations

¹ Newborn Research Center and Neonatal Services, The Royal Women's Hospital, Melbourne, Victoria, Australia; Department of Neonatology, University Hospital and University of Zürich, Switzerland.
² Newborn Research Center and Neonatal Services, The Royal Women's Hospital, Melbourne, Victoria, Australia; Department of Neonatology, University Children's Hospital of Tübingen, Germany.
³ Newborn Research Center and Neonatal Services, The Royal Women's Hospital, Melbourne, Victoria, Australia; Department of Obstetrics and Gynecology, The University of Melbourne, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
⁴ Department of Neonatology, University Hospital and University of Zürich, Switzerland.
⁵ Department of Obstetrics and Gynecology, The University of Melbourne, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Neonatology, The Royal Children's Hospital, Melbourne, Victoria, Australia.
⁶ Department of Obstetrics and Gynecology, The University of Melbourne, Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

PMID: 29954606
DOI: 10.1016/j.jpeds.2018.05.029

Abstract

Noninvasive high-frequency oscillatory ventilation compared with nasal continuous positive airway pressure significantly reduced the number of desaturations and bradycardia in preterm infants. However, noninvasive high-frequency oscillatory ventilation was associated with increased oxygen requirements and higher heart rates.

Trial registration: Australian and New Zealand Clinical Trial Registry: ACTRN12616001516471.

Keywords: apnea of prematurity; nasal high frequency oscillatory ventilation; noninvasive ventilation.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Bradycardia / metabolism
Bradycardia / prevention & control*
Cross-Over Studies
Follow-Up Studies
High-Frequency Ventilation / methods*
Humans
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight*
Oxygen Consumption
Prospective Studies
Respiratory Distress Syndrome, Newborn / metabolism
Respiratory Distress Syndrome, Newborn / prevention & control*
Treatment Outcome