The effect of bromodeoxyuridine on the segregation of the chicken-specific HPRT gene from Chinese hamster-chick red blood cell somatic hybrids

Exp Cell Res. 1978 May;113(2):339-43. doi: 10.1016/0014-4827(78)90374-9.

Abstract

The segregation of the chick-specific HPRT gene was studied in three Chinese hamster-chick red blood cell hybrid lines. The three lines showed individual segregation kinetics, the segregation taking place in an exponential-like fashion. Bromodeoxyuridine becomes incorporated into the nuclear DNA and increases the spontaneous segregation rate.

MeSH terms

  • Animals
  • Bromodeoxyuridine / pharmacology*
  • Cell Cycle
  • Chickens
  • Genes / drug effects*
  • Hybrid Cells / cytology
  • Hybrid Cells / drug effects*
  • Hypoxanthine Phosphoribosyltransferase / genetics
  • Karyotyping
  • Phenotype
  • Species Specificity

Substances

  • Hypoxanthine Phosphoribosyltransferase
  • Bromodeoxyuridine