Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

Joe-Elie Salem; Xavier Waintraub; Carine Courtillot; Christian M Shaffer; Estelle Gandjbakhch; Carole Maupain; Javid J Moslehi; Fabio Badilini; Julien Haroche; Paul Gougis; Veronique Fressart; Andrew M Glazer; Francoise Hidden-Lucet; Philippe Touraine; Benedicte Lebrun-Vignes; Dan M Roden; Anne Bachelot; Christian Funck-Brentano

doi:10.1161/CIRCULATIONAHA.118.034282

Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

Circulation. 2018 Jul 3;138(1):110-113. doi: 10.1161/CIRCULATIONAHA.118.034282.

Authors

Joe-Elie Salem^{1

2

3

4

5

6

7}, Xavier Waintraub^{2

4}, Carine Courtillot^{8

9}, Christian M Shaffer⁶, Estelle Gandjbakhch^{2

4

5}, Carole Maupain^{2

4}, Javid J Moslehi⁷, Fabio Badilini¹⁰, Julien Haroche^{11

12}, Paul Gougis^{13

3

5}, Veronique Fressart^{2

4}, Andrew M Glazer⁶, Francoise Hidden-Lucet^{2

4}, Philippe Touraine^{8

9

5}, Benedicte Lebrun-Vignes^{13

3

5}, Dan M Roden⁶, Anne Bachelot^{8

9

5}, Christian Funck-Brentano^{13

3

5}

Affiliations

¹ Department of Pharmacology, Pharmacovigilance Unit (J.-E.S., P.G., B.L.-V., C.F.-B.) joe-elie.salem@aphp.fr joe-elie.salem@vanderbilt.edu.
² Department of Cardiology, CIC 1421, Cardiogenetic Unit, Arrhythmology Unit (J.-E.S., X.W., E.G., C.M., V.F., F.H.-L.).
³ Institut National de la Santé et de la Recherche Médicale (J.-E.S., P.G., B.L.-V., C.F.-B.).
⁴ UMR Institute of Cardiometabolism and Nutrition (J.-E.S., X.W., E.G., C.M., V.F., F.H.-L.), Paris, France.
⁵ Sorbonne Université, Faculty of Medicine, Paris, France (J.-E.S., P.G., B.L.-V., C.F.-B., A.B., P.T., E.G.).
⁶ Departments of Medicine, Pharmacology, and Biomedical Informatics (J.-E.S., C.M.S., A.M.G., D.M.R.).
⁷ Departments of Medicine, Cardiology, and Cardio-Oncology Program, Vanderbilt University Medical Center, Nashville, TN (J.-E.S., J.J.M.).
⁸ Department of Endocrinology and Reproductive Medicine (C.C., P.T., A.B.), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
⁹ Centre de Référence des Maladies Endocriniennes Rares de la Croissance et Centre des Pathologies Gynécologiques Rares (C.C., P.T., A.B.).
¹⁰ AMPS LLC, New York, NY (F.B.).
¹¹ Department of Internal Medicine (J.H.).
¹² Sorbonne Université, Faculty of Medicine, Paris, France (J.H.).
¹³ Department of Pharmacology, Pharmacovigilance Unit (J.-E.S., P.G., B.L.-V., C.F.-B.).

No abstract available

Keywords: androgen antagonists; androgens; antineoplastic agents; hypogonadism; men; testosterone; torsades de pointes.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adverse Drug Reaction Reporting Systems
Aged
Aged, 80 and over
Androgen Antagonists / adverse effects
Biomarkers / blood
Cross-Sectional Studies
Databases, Factual
Electronic Health Records
Heart Rate*
Hormone Replacement Therapy
Humans
Hypogonadism / blood
Hypogonadism / complications*
Hypogonadism / diagnosis
Hypogonadism / drug therapy
Male
Middle Aged
Paris
Pharmacovigilance
Prospective Studies
Risk Assessment
Risk Factors
Testosterone / blood
Testosterone / deficiency*
Testosterone / therapeutic use
Torsades de Pointes / diagnosis
Torsades de Pointes / etiology*
Torsades de Pointes / physiopathology
Torsades de Pointes / prevention & control

Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

Authors

Affiliations

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