[Atypical distal tibial shaft fractures in a patient with bilateral TKA and antiresorptive treatment]

Orthopade. 2018 Aug;47(8):688-691. doi: 10.1007/s00132-018-3596-6.
[Article in German]

Abstract

There are many cases in the literature that describe atypical femur fractures under antiresorptive therapy. Other localizations of fractures of this genesis, especially if occurring bilaterally, are rare. This case reports about the diagnosis, treatment and process of a 76-year old patient, who within a 4‑month period suffered from bilateral distal tibial shaft fractures, after years of treatment with bisphosphonates, strontium ranelate and denosumab.

In der Literatur lassen sich viele beschriebene Fälle von atypischen Femurfrakturen unter antiresorptiver Therapie finden. Andere Lokalisationen von Frakturen dieser Genese, zudem bilateral aufgetreten, sind Raritäten. Dieser Fall berichtet über Diagnostik, Therapie und Verlauf bei einer 76-jährigen Patientin, welche nach jahrelanger Therapie mit Bisphosphonaten, Strontiumranelat und Denosumab binnen 4 Monaten beidseits distale Tibiaschaftquerfrakturen ohne adäquates Trauma erlitt.

Keywords: Antiresorptive drugs; Bisphosphonates; Denosumab; Knee arthroplasty, total; Osteoporosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Arthroplasty, Replacement, Knee*
  • Bone Density Conservation Agents* / administration & dosage
  • Bone Density Conservation Agents* / adverse effects
  • Denosumab
  • Diphosphonates
  • Femoral Fractures* / etiology
  • Humans

Substances

  • Bone Density Conservation Agents
  • Diphosphonates
  • Denosumab