Mitochondrial Shapeshifting Impacts AML Stemness and Differentiation

Cell Stem Cell. 2018 Jul 5;23(1):3-4. doi: 10.1016/j.stem.2018.05.026.

Abstract

In this issue of Cell Stem Cell, Pei et al. (2018) demonstrate that leukemic stem cells (LSCs) have enhanced mitochondrial fission, which is positively regulated by FIS1. FIS1 is necessary to maintain LSC function; thus, targeting its expression and mitochondrial fission is a novel approach to decrease stemness and increase differentiation in Acute Myeloid Leukemia.

Publication types

  • Comment

MeSH terms

  • AMP-Activated Protein Kinases
  • Cell Differentiation
  • Humans
  • Leukemia, Myeloid, Acute*
  • Membrane Proteins
  • Mitochondrial Proteins
  • Mitophagy*
  • Neoplastic Stem Cells

Substances

  • FIS1 protein, human
  • Membrane Proteins
  • Mitochondrial Proteins
  • AMP-Activated Protein Kinases