T-Cell Receptor Excision Circles in HIV-Exposed, Uninfected Newborns Measured During a National Newborn Screening Program for Severe Combined Immunodeficiency

J Pediatr. 2018 Nov:202:311-314.e2. doi: 10.1016/j.jpeds.2018.06.008. Epub 2018 Jul 3.

Abstract

Severe combined immunodeficiency screening by measuring T-receptor excision circles at birth allows evaluation of the impact of various maternal conditions on newborn immunity. The slight decrease observed in a French cohort of newborns to HIV-infected mothers can be explained by the confounding factors of prematurity and African descent.

Keywords: HIV; T cell; TREC; lymphocyte; newborn; pregnancy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • France
  • Genetic Testing
  • HIV Infections / diagnosis
  • HIV Infections / immunology*
  • HIV Seropositivity
  • Humans
  • Infant, Newborn
  • Male
  • Neonatal Screening / methods*
  • Polymerase Chain Reaction / methods
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Complications, Infectious / virology
  • Receptors, Antigen, T-Cell / genetics*
  • Reference Values
  • Retrospective Studies
  • Severe Combined Immunodeficiency / diagnosis
  • Severe Combined Immunodeficiency / epidemiology
  • Severe Combined Immunodeficiency / genetics*

Substances

  • Anti-HIV Agents
  • Receptors, Antigen, T-Cell