Spontaneous hematoma of the thigh associated with antiproteinase-3 antibody in a patient with metastatic squamous cell carcinoma treated with nivolumab

J Oncol Pharm Pract. 2019 Jul;25(5):1261-1264. doi: 10.1177/1078155218786352. Epub 2018 Jul 9.

Abstract

We report an unusual case of spontaneous intramuscular hematoma associated with antiproteinase 3 antibody in a patient with metastatic squamous cell carcinoma receiving nivolumab and the medical literature is reviewed.

Keywords: PD-1/PD-L1 inhibitor; nivolumab; spontaneous hematoma; squamous cell carcinoma of lung.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Immunological / adverse effects*
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / immunology
  • Carcinoma, Squamous Cell / secondary
  • Hematoma / etiology*
  • Humans
  • Male
  • Middle Aged
  • Myeloblastin / immunology*
  • Nivolumab / adverse effects*
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors*
  • Thigh
  • Tonsillar Neoplasms / pathology*

Substances

  • Antineoplastic Agents, Immunological
  • Programmed Cell Death 1 Receptor
  • Nivolumab
  • Myeloblastin