Successful Empiric Therapy for Postsplenectomy Sepsis with Campylobacter fetus in an Abattoir Worker with Follicular Lymphoma

Intern Med. 2018 Nov 15;57(22):3329-3332. doi: 10.2169/internalmedicine.1031-18. Epub 2018 Jul 6.

Abstract

Asplenia may yield an increased risk of fulminant sepsis with various pathogens. Human infection with Campylobacter fetus is rare, but it often presents with non-gastrointestinal tract infection among immunocompromised individuals. A 55-year-old abattoir worker presented with a fever. He had had splenectomy for follicular lymphoma and rituximab maintenance therapy by four months before the presentation. Blood cultures yielded C. fetus, and the administration of meropenem dissolved the bacteremia. Further maintenance therapy was withheld, and no recurrence of infection has been observed for seven years. Asplenia, occupational exposure, and/or rituximab maintenance therapy might have been precipitating factors of this rare infection.

Keywords: Campylobacter fetus; abattoir; follicular lymphoma; rituximab; sepsis; splenectomy.

Publication types

  • Case Reports

MeSH terms

  • Abattoirs
  • Anti-Bacterial Agents / therapeutic use*
  • Campylobacter Infections / complications*
  • Campylobacter Infections / drug therapy
  • Campylobacter fetus / isolation & purification*
  • Humans
  • Immunocompromised Host
  • Lymphoma, Follicular / complications*
  • Lymphoma, Follicular / diagnosis
  • Male
  • Middle Aged
  • Rituximab
  • Sepsis / complications*
  • Sepsis / drug therapy
  • Sepsis / microbiology
  • Splenectomy / adverse effects*
  • Surgical Wound Infection / complications*
  • Surgical Wound Infection / drug therapy
  • Surgical Wound Infection / microbiology

Substances

  • Anti-Bacterial Agents
  • Rituximab