TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

Org Biomol Chem. 2018 Jul 25;16(29):5228-5231. doi: 10.1039/c8ob01380b.

Abstract

Highly selective and catalyst-free tandem multi-functionalization of terminal alkynes was developed with 2-oxindoles and benzo-furan-2(3H)-one using TEMPO both as a radical promoter and a trapping reagent. This work expands the scope of the radical-cascade addition/trapping process of alkynes for the effective construction of various β-oxyl carbonyls in moderate to good yields.

Publication types

  • Research Support, Non-U.S. Gov't