Physical comorbidities in older adults receiving antidepressants in Asia

Psychogeriatrics. 2018 Sep;18(5):351-356. doi: 10.1111/psyg.12327. Epub 2018 Jul 10.

Abstract

Background: The present study explored the patterns of physical comorbidities and their associated demographic and clinical factors in older psychiatric patients prescribed with antidepressants in Asia.

Methods: Demographic and clinical information of 955 older adults were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Standardized data collection procedure was used to record demographic and clinical data.

Results: Proportion of physical comorbidities in this cohort was 44%. Multiple logistic regression analyses showed that older age (OR = 1.7, P < 0.001), higher number of depressive symptoms (OR = 1.09, P = 0.016), being treated in psychiatric hospital (OR = 0.5, P = 0.002), living in high income countries/territories (OR = 2.4, P = 0.002), use of benzodiazepines (OR = 1.4, P = 0.013) and diagnosis of 'other psychiatric disorders' (except mood, anxiety disorders and schizophrenia) (OR = 2.7, P < 0.001) were significantly associated with physical comorbidities.

Conclusions: Physical comorbidities in older patients prescribed with antidepressants were common in Asia. Integrating physical care into the treatment of older psychiatric patients should be urgently considered.

Keywords: Asia; antidepressant; older adults; physical comorbidity.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antidepressive Agents / therapeutic use*
  • Anxiety Disorders / drug therapy*
  • Asia / epidemiology
  • Cerebrovascular Disorders / epidemiology
  • Comorbidity
  • Depression / drug therapy*
  • Depression / epidemiology
  • Diabetes Mellitus / epidemiology
  • Drug Prescriptions / statistics & numerical data*
  • Female
  • Humans
  • Male
  • Mood Disorders / drug therapy*
  • Mood Disorders / epidemiology
  • Schizophrenia / drug therapy*
  • Schizophrenia / epidemiology

Substances

  • Antidepressive Agents