Lumbar drains can affect CSF biomarker levels

J Clin Pathol. 2019 Jan;72(1):91-92. doi: 10.1136/jclinpath-2018-205296. Epub 2018 Jul 11.

Authors

Claudia Louise Craven¹, Miles D Chapman², Linda D'Antona¹, Simon D Thompson¹, Neghat Lakdawala², Henrik Zetterberg^{3

4

5}, Laurence D Watkins¹, Ahmed K Toma¹

Affiliations

¹ Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
² Department of Neuroimmunology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
³ Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
⁴ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
⁵ UK Dementia Research Institute at UCL, London, UK.

PMID: 29997233
DOI: 10.1136/jclinpath-2018-205296

No abstract available

Keywords: amyloid; csf biochemistry; dementia; neurodegeneration; neuropathology.

Publication types

Letter

MeSH terms

Alzheimer Disease / cerebrospinal fluid*
Alzheimer Disease / diagnosis
Amyloid beta-Peptides / cerebrospinal fluid*
Biomarkers / cerebrospinal fluid
Catheters, Indwelling
Drainage / instrumentation
Drainage / methods*
Equipment Design
Humans
Hydrocephalus, Normal Pressure / cerebrospinal fluid*
Hydrocephalus, Normal Pressure / diagnosis
Lumbar Vertebrae
Peptide Fragments / cerebrospinal fluid*
Predictive Value of Tests
Reproducibility of Results
Specimen Handling / instrumentation
Specimen Handling / methods*
tau Proteins / cerebrospinal fluid*

Substances

Amyloid beta-Peptides
Biomarkers
MAPT protein, human
Peptide Fragments
amyloid beta-protein (1-42)
tau Proteins