Bone Disease in Mastocytosis

Immunol Allergy Clin North Am. 2018 Aug;38(3):443-454. doi: 10.1016/j.iac.2018.04.013.

Abstract

Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinical relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures. The main factor of bone loss is the osteoclast with a relative or absolute predominance of bone resorption. The RANK-RANKL pathway seems of key importance, but histamine and other cytokines also play a significant role in the process. The predominance of resorption made bisphosphonates, as anti-resorptive drugs, the most rational treatment of bone involvement in systemic mastocytosis.

Keywords: Bone mineral density; Bone turnover markers; Fracture; Mastocytosis; Osteoporosis; Osteosclerosis.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Bone Density Conservation Agents / therapeutic use
  • Bone Diseases / immunology*
  • Bone Diseases / therapy
  • Bone Resorption
  • Diphosphonates / metabolism
  • Humans
  • Mastocytosis, Systemic / immunology*
  • Mastocytosis, Systemic / therapy
  • Osteoclasts / physiology*
  • RANK Ligand / metabolism
  • Receptor Activator of Nuclear Factor-kappa B / metabolism
  • Signal Transduction

Substances

  • Bone Density Conservation Agents
  • Diphosphonates
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B