Correlation between high expression levels of jumonji domain-containing 4 and short survival in cases of colon adenocarcinoma

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1442-1449. doi: 10.1016/j.bbrc.2018.07.061. Epub 2018 Jul 17.

Abstract

In this study, we investigated the expression of jumonji domain-containing 4 (JMJD4) in colon adenocarcinoma (CA) look for evidences for future studies on clinical diagnostic and prognostic value. The immunohistochemical (IHC) reactivity of JMJD4 was assessed in human tissue microarrays using monoclonal antibodies. An initial investigation revealed that the expression of JMJD4 protein was significantly higher in tumor tissue of the colon and liver than in normal tissue. Upon further investigation, we observed significant positivity of JMJD4 between 59 paired samples from CA tissue and adjacent normal tissue. JMJD4 protein expression in CA differed significantly according to the histological grade and M-class (distant metastasis). We also determined that the mRNA or protein expression of JMJD4 was significantly associated with poor survival in patients with CA. Finally, univariate and multivariate analysis revealed that JMJD4 expression could be a prognostic indicator for patients with CA and may provide a new target for the development of novel therapies for the treatment of CA.

Keywords: Colon adenocarcinoma; Colorectal cancer; Immunohistochemistry; JMJD4; Prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / genetics*
  • Colonic Neoplasms / diagnosis
  • Colonic Neoplasms / genetics*
  • Female
  • Humans
  • Immunohistochemistry
  • Jumonji Domain-Containing Histone Demethylases
  • Male
  • Middle Aged
  • Mixed Function Oxygenases / analysis
  • Mixed Function Oxygenases / genetics*
  • RNA, Messenger / genetics
  • Survival Rate

Substances

  • RNA, Messenger
  • Mixed Function Oxygenases
  • JMJD4 protein, human
  • Jumonji Domain-Containing Histone Demethylases