A core-shell nanoparticle-peptide@metal-organic framework as pH and enzyme dual-recognition switch for stepwise-responsive imaging in living cells

Chem Commun (Camb). 2018 Aug 14;54(66):9155-9158. doi: 10.1039/c8cc04621b.

Abstract

A core-shell nanostructure is fabricated with a pH-sensitive metal-organic framework shell and a peptide functionalized gold nanoparticle core via a mild synthetic route. The nanostructure can be applied as a dual-recognition switch in response to an acidic environment and enzyme activity, sequentially, leading to a stepwise-responsive strategy for imaging lysosomal cathepsin B.

MeSH terms

  • Carbocyanines / chemistry
  • Carbocyanines / toxicity
  • Cathepsin B / analysis*
  • Fluorescence
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / toxicity
  • Gold / chemistry
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Imidazoles / chemistry
  • Imidazoles / toxicity
  • Lysosomes / metabolism
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / toxicity
  • Metal-Organic Frameworks / chemistry*
  • Metal-Organic Frameworks / toxicity
  • Microscopy, Confocal / methods
  • Microscopy, Fluorescence / methods
  • Particle Size
  • Peptides / chemistry
  • Peptides / toxicity
  • Zeolites / chemistry
  • Zeolites / toxicity

Substances

  • Carbocyanines
  • Fluorescent Dyes
  • Imidazoles
  • Metal-Organic Frameworks
  • Peptides
  • cyanine dye 3
  • Zeolites
  • Gold
  • Cathepsin B