Neuroleptic malignant syndrome following reintroduction of an antipsychotic after overdose

Théo Korchia; Graham Blackman; Michel Cermolacce; Raphaëlle Richieri

doi:10.1136/bcr-2017-223922

Neuroleptic malignant syndrome following reintroduction of an antipsychotic after overdose

BMJ Case Rep. 2018 Aug 3:2018:bcr2017223922. doi: 10.1136/bcr-2017-223922.

Authors

Théo Korchia¹, Graham Blackman², Michel Cermolacce¹, Raphaëlle Richieri^{1

2

3}

Affiliations

¹ Department of Psychiatry, Assistance Publique Hopitaux de Marseille, Marseille, France.
² Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
³ Institut Fresnel - UMR 7249, Faculté des Sciences de Saint Jérôme, Marseille, France.

Abstract

Neuroleptic malignant syndrome (NMS) is a potentially lethal adverse drug reaction. We report a case of NMS potentially induced by dehydration in a female patient suffering from schizoaffective disorder. We discuss possible aetiologies and triggering factors alongside the existing literature.

Keywords: psychiatry (drugs and medicines); unwanted effects / adverse reactions.

Publication types

Case Reports

MeSH terms

Antipsychotic Agents / adverse effects*
Benzodiazepines / therapeutic use
Clopenthixol / adverse effects
Dehydration / complications
Drug Overdose / complications*
Female
Fluid Therapy / methods
Humans
Middle Aged
Neuroleptic Malignant Syndrome / etiology*
Neuroleptic Malignant Syndrome / therapy
Neuromuscular Agents / therapeutic use
Psychotic Disorders / drug therapy

Substances

Antipsychotic Agents
Neuromuscular Agents
Benzodiazepines
Clopenthixol