Objective: To describe the distributions of the diabetes related gene variants among Chinese population born in early 1960s.
Methods: A total of 1983 subjects( 770 male, 1213 female) were selected from the cross-sectional 2010-2012 China National Nutrition and Health Surveillance. The 45 diabetes related single nucleotide polymorphism( SNPs) were detected by the Mass Array. The distributions of these risk allele in the current study were compared with the result of Utah residents with Northern and Western European ancestry, Japanese in Tokyo, African ancestry inSouthwest USA and Han Chinese in Beijing from the 1000 Genomes project.
Results: Among Chinese population born in 1960-1961 and 1963, significant differences in the frequency of the risk allele of rs17584499, rs10906115, rs10886471 and rs11257655 were found between male and female. Compared to the female population, the male have the higher frequency in rs17584499( χ~2= 4. 270, P = 0. 039) and rs10906115( χ~2= 4. 254, P = 0. 039), while lower frequency of risk allele in rs10886471( χ~2= 6. 199, P = 0. 013)and rs11257655( χ~2= 5. 644, P = 0. 018). There was ethnic difference in the frequency of most of the risk alleles, and the difference between the Chinese population and the European ancestry or African ancestry were higher than between the Chinese population and Japanese population.
Conclusion: The distributions of the diabetes risk alleles among the Chinese population born in early 1960 s have slight gender difference only in few SNPs. There is significant ethnic difference in the frequency of risk allele in most of the diabetes related SNPs.
Keywords: diabetes; ethnics; risk allele frequency; single nucleotide polymorphism.