Molybdenum- and tungsten-containing formate dehydrogenases and formylmethanofuran dehydrogenases: Structure, mechanism, and cofactor insertion

Protein Sci. 2019 Jan;28(1):111-122. doi: 10.1002/pro.3498. Epub 2018 Oct 31.

Abstract

An overview is provided of the molybdenum- and tungsten-containing enzymes that catalyze the interconversion of formate and CO2 , focusing on common structural and mechanistic themes, as well as a consideration of the manner in which the mature Mo- or W-containing cofactor is inserted into apoprotein.

Keywords: formate dehydrogenase; formylmethanofuran dehydrogenase; molybdenum; tungsten.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Systematic Review

MeSH terms

  • Aldehyde Oxidoreductases / chemistry*
  • Aldehyde Oxidoreductases / metabolism
  • Catalysis
  • Coenzymes / chemistry*
  • Coenzymes / metabolism
  • Formate Dehydrogenases / chemistry*
  • Formate Dehydrogenases / metabolism
  • Molybdenum / chemistry*
  • Molybdenum / metabolism
  • Structure-Activity Relationship
  • Tungsten / chemistry*
  • Tungsten / metabolism

Substances

  • Coenzymes
  • Molybdenum
  • Formate Dehydrogenases
  • Aldehyde Oxidoreductases
  • formylmethanofuran dehydrogenase
  • Tungsten