New Naphthalene Derivatives from the Bulbs of Eleutherine americana with Their Protective Effect on the Injury of HUVECs

Molecules. 2018 Aug 22;23(9):2111. doi: 10.3390/molecules23092111.

Abstract

Five new naphthalene derivatives, named Eleutherols A⁻C (1⁻3) and Eleuthinones B⁻C (4,5), together with three known compounds were isolated from the bulbs of Eleutherine americana. Their structures were elucidated on the basis of spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR techniques. These compounds exhibited a potent effect against the injury of human umbilical vein endothelial cell (HUVECs) induced by high concentrations of glucose in vitro.

Keywords: Eleutherine americana; HUVECs; naphthalene derivatives.

MeSH terms

  • Endothelial Cells / drug effects*
  • Endothelial Cells / metabolism
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Naphthalenes / chemistry*
  • Naphthalenes / pharmacology*
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry*
  • Protective Agents / pharmacology
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Naphthalenes
  • Plant Extracts
  • Protective Agents