Cryo-EM structure of the human α5β3 GABAA receptor

Si Liu; Lingyi Xu; Fenghui Guan; Yun-Tao Liu; Yanxiang Cui; Qing Zhang; Xiang Zheng; Guo-Qiang Bi; Z Hong Zhou; Xiaokang Zhang; Sheng Ye

doi:10.1038/s41422-018-0077-8

Cryo-EM structure of the human α5β3 GABA_A receptor

Cell Res. 2018 Sep;28(9):958-961. doi: 10.1038/s41422-018-0077-8. Epub 2018 Aug 23.

Authors

Si Liu¹, Lingyi Xu², Fenghui Guan², Yun-Tao Liu^{3

4

5}, Yanxiang Cui⁶, Qing Zhang^{7

8}, Xiang Zheng², Guo-Qiang Bi^{3

4

5

9}, Z Hong Zhou^{10

11}, Xiaokang Zhang^{12

13}, Sheng Ye^{14

15}

Affiliations

¹ Life Sciences Institute and School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
² Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
³ Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China (USTC), Hefei, Anhui, 230026, P. R. China.
⁴ School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
⁵ CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
⁶ Electron Imaging Center for Nanomachines, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
⁷ Department of Biophysics, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
⁸ Center of Cryo Electron Microscopy, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
⁹ CAS Center for Excellence in Brain Science and Intelligence Technology, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
¹⁰ Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA. hong.zhou@ucla.edu.
¹¹ California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA. hong.zhou@ucla.edu.
¹² Department of Biophysics, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China. xzhang1965@zju.edu.cn.
¹³ Center of Cryo Electron Microscopy, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China. xzhang1965@zju.edu.cn.
¹⁴ Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China. sye@zju.edu.cn.
¹⁵ School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, P. R. China. sye@zju.edu.cn.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cryoelectron Microscopy*
HEK293 Cells
Humans
Models, Molecular
Protein Conformation
Receptors, GABA-A / chemistry*
Receptors, GABA-A / ultrastructure*

Substances

Receptors, GABA-A

Publication types

MeSH terms

Substances

Grants and funding