Endoplasmic Reticulum: Target for Next-Generation Cancer Therapy

Samya Banerjee; Wenying Zhang

doi:10.1002/cbic.201800461

Endoplasmic Reticulum: Target for Next-Generation Cancer Therapy

Chembiochem. 2018 Nov 16;19(22):2341-2343. doi: 10.1002/cbic.201800461. Epub 2018 Oct 15.

Authors

Samya Banerjee¹, Wenying Zhang¹

Affiliation

¹ Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

PMID: 30176182
DOI: 10.1002/cbic.201800461

Abstract

Tumour-targeting and selective ER stress inducers: Small-molecule compounds that target the endoplasmic reticulum (ER) and induce ER stress are emerging as next-generation anticancer agents. This highlight discusses a few current works on this topic and its enormous potential in the fight against cancer.

Keywords: ER stress; ER targeting; antitumor agents; endoplasmic reticulum; imaging agents.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Endoplasmic Reticulum / drug effects*
Endoplasmic Reticulum Stress / drug effects*
Humans
Neoplasms / drug therapy*

Substances

Antineoplastic Agents