Abstract
Asmic addresses the long-standing challenge of alkylating isocyanides, providing access to isocyanides with diverse substitution patterns. The o-anisylsulfanyl group serves a critical dual role by facilitating deprotonation-alkylation and providing a latent nucleophilic site through an unusual arylsulfanyl-lithium exchange.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemical synthesis*
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Alkanes / chemistry
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Alkylation
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Cyanides / chemistry*
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Lithium / chemistry
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Molecular Structure
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Organometallic Compounds / chemistry
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Sulfhydryl Compounds / chemistry
Substances
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Alkanes
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Cyanides
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Organometallic Compounds
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Sulfhydryl Compounds
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Lithium