Genome-wide association study in Guillain-Barré syndrome

Stefan Blum; Ying Ji; David Pennisi; Zhixiu Li; Paul Leo; Pamela McCombe; Matthew A Brown

doi:10.1016/j.jneuroim.2018.07.016

Genome-wide association study in Guillain-Barré syndrome

J Neuroimmunol. 2018 Oct 15:323:109-114. doi: 10.1016/j.jneuroim.2018.07.016. Epub 2018 Aug 2.

Authors

Stefan Blum¹, Ying Ji², David Pennisi³, Zhixiu Li³, Paul Leo³, Pamela McCombe¹, Matthew A Brown⁴

Affiliations

¹ The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, Brisbane, Australia.
² Translational Genomics Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Australia; Department of Neurology, Peking University Third Hospital, Beijing, PR China.
³ Translational Genomics Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Australia.
⁴ Translational Genomics Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Australia. Electronic address: Matt.brown@qut.edu.au.

PMID: 30196823
DOI: 10.1016/j.jneuroim.2018.07.016

Abstract

Guillain-Barré syndrome (GBS) is considered to have an immune-mediated basis, but the genetic contribution to GBS is unclear. We conducted a GWAS involving 215 GBS patients and 1,105 healthy controls. No significant associations of individual SNPs or imputed HLA types were observed. We performed a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the disease. Genetic risk score analysis showed no evidence of overlap in genetic susceptibility factors of GBS and multiple sclerosis. Given the unexplained heritability of the trait further larger GWAS are indicated.

Keywords: Case-control study; Genetic risk score; Genome-wide association study; Guillain-Barré syndrome; Heritability; Human leukocyte antigen (HLA) genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study / methods*
Guillain-Barre Syndrome / diagnosis*
Guillain-Barre Syndrome / epidemiology
Guillain-Barre Syndrome / genetics*
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Young Adult