First Locally Acquired Congenital Zika Syndrome Case in the United States: Neonatal Clinical Manifestations

Ophthalmic Surg Lasers Imaging Retina. 2018 Sep 1;49(9):e93-e98. doi: 10.3928/23258160-20180907-14.

Abstract

In the spring of 2017, a full-term infant with microcephaly was delivered in South Florida. During first trimester, the mother presented with fever, nausea, and vomiting. She reported no foreign travel for herself or her partner. The infant's neurologic, ophthalmologic, neuroradiologic, and audiologic findings were highly suggestive of congenital Zika syndrome (CZS), confirmed by IgM antibodies and plaque reduction neutralization test. New observations, including peripheral temporal retinal avascularity and peripapillary retinal nerve fiber layer thinning, are presented from this first known case of non-travel-associated CZS in the United States. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:e93-e98.].

Publication types

  • Case Reports

MeSH terms

  • Corneal Dystrophies, Hereditary / diagnosis*
  • Eye Infections, Viral / diagnosis*
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Microcephaly / diagnosis*
  • Optic Nerve Diseases / diagnosis*
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • RNA, Viral / genetics
  • Real-Time Polymerase Chain Reaction
  • Ultrasonography, Prenatal
  • United States
  • Young Adult
  • Zika Virus / genetics
  • Zika Virus Infection / congenital
  • Zika Virus Infection / diagnosis*

Substances

  • RNA, Viral

Supplementary concepts

  • Chorioretinal atrophy, progressive bifocal