Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.
Keywords: cancer stem cell; cell cycle; colorectal cancer; dormancy; hedgehog; heterogeneity; itraconazole; plasticity; wnt.