[Tuberculosis in older persons in African setting: Epidemiological, diagnostic and evolutive features]

Abstract

Objective: To determine the epidemiological, diagnostic and evolutives features of tuberculosis (TB) in older subjects in Benin.

Patients and methods: This was a retrospective cohort study of adults TB patients (age≥15 years) who were notified at all the Basic Management Units (BMU) in Benin from January 1st, 2013 to December 31st. Older subjects (age≥60 years) were compared to those less than 60 years named young subjects. The threshold of significance was set at 5%.

Results: The analysis was carried out on 6531 cases adults cases notified during the period. 601 (9.2%) were 60 years old or above. The case notification rate (CNR) in elders was more than twice the CNR in young people (68 cases vs. 31 cases per 100,000 population). Older subjects were less often infected with HIV (9.3%) than young's (16.7%), P<0.0001. In new bacteriologically confirmed pulmonary TB negative for HIV, unfavorable treatment outcomes were more frequent in older subjects than in young subjects with more deaths (7.5% vs. 3.0%). On the other hand, in bacteriological confirmed TB seropositive for HIV and all the other cases, treatment outcomes were comparable between the two groups.

Conclusion: The high CNR and the high death rate in older subjects should plead for a specific care for an adapted management of TB case in this group.

Keywords: Africa; Afrique; Benin; Bénin; Older patients; Sujet âgé; Tuberculose; Tuberculosis.