Cancer Mutations in SPOP Put a Stop to Its Inter-compartmental Hops

Julia F Riley; Thuy P Dao; Carlos A Castañeda

doi:10.1016/j.molcel.2018.09.025

Cancer Mutations in SPOP Put a Stop to Its Inter-compartmental Hops

Mol Cell. 2018 Oct 4;72(1):1-3. doi: 10.1016/j.molcel.2018.09.025.

Authors

Julia F Riley¹, Thuy P Dao², Carlos A Castañeda³

Affiliations

¹ Departments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA; Program in Neuroscience, Syracuse University, Syracuse, NY 13244, USA.
² Departments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA.
³ Departments of Biology and Chemistry, Syracuse University, Syracuse, NY 13244, USA; Program in Neuroscience, Syracuse University, Syracuse, NY 13244, USA. Electronic address: cacastan@syr.edu.

PMID: 30290146
DOI: 10.1016/j.molcel.2018.09.025

Abstract

In this issue of Molecular Cell, Bouchard et al. (2018) identify liquid-liquid phase separation as a mechanism for substrate-triggered localization of SPOP and ubiquitination machinery to different nuclear bodies and describe how cancer mutations disrupt this process.

Publication types

Comment

MeSH terms

Humans
Humulus*
Male
Mutation
Nuclear Proteins / genetics
Prostatic Neoplasms*
Repressor Proteins / genetics

Substances

Nuclear Proteins
Repressor Proteins
SPOP protein, human