Potassium channels in the sinoatrial node and their role in heart rate control

Channels (Austin). 2018;12(1):356-366. doi: 10.1080/19336950.2018.1532255.

Abstract

Potassium currents determine the resting membrane potential and govern repolarisation in cardiac myocytes. Here, we review the various currents in the sinoatrial node focussing on their molecular and cellular properties and their role in pacemaking and heart rate control. We also describe how our recent finding of a novel ATP-sensitive potassium channel population in these cells fits into this picture.

Keywords: ATP-sensitive potassium channel; heart rate; pacemaking; potassium channel; sinoatrial node.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Heart Rate / physiology*
  • Humans
  • Potassium Channels / metabolism*
  • Sinoatrial Node / metabolism*

Substances

  • Potassium Channels