Pulmonary function assessment post-left ventricular assist device implantation

Abstract

Aim: The lungs-and particularly the alveolar-capillary membrane-may be sensitive to continuous flow (CF) and pulmonary pressure alterations in heart failure (HF). We aimed to investigate long-term effects of CF pumps on respiratory function.

Methods and results: We conducted a retrospective study of patients with end-stage HF at our institution. We analysed pulmonary function tests [e.g. forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV₁ )] and diffusing capacity of the lung for carbon monoxide (D_LCO ) from before and after left ventricular assist device (LVAD) implantation and compared them with invasive haemodynamic studies. Of the 274 patients screened, final study analysis involved 44 patients with end-stage HF who had CF LVAD implantation between 1 February 2007 and 31 December 2015 at our institution. These patients [mean (standard deviation, SD) age, 50 (9) years; male sex, n = 33, 75%] received either the HeartMate II (Thoratec Corp.) pump (77%) or the HeartWare (HeartWare International Inc.) pump. The mean (SD) left ventricular ejection fraction was 21% (13%). At a median of 237 days post-LVAD implantation, we observed significant D_LCO decrease (-23%) since pre-implantation (P < 0.001). ΔD_LCO had an inverse relationship with changes in pulmonary capillary wedge pressure (PCWP) and right atrial pressure (RAP) from pre-LVAD to post-LVAD implantation: ΔD_LCO to ΔPCWP (r = 0.50, P < 0.01) and ΔD_LCO to ΔRAP (r = 0.39, P < 0.05). We observed other reductions in FEV₁ , FVC, and FEV₁ /FVC between pre-LVAD and post-LVAD implantation. In mean (SD) values, FEV₁ changed from 2.3 (0.7) to 2.1 (0.7) (P = 0.005); FVC decreased from 3.2 (0.8) to 2.9 (0.9) (P = 0.01); and FEV₁ /FVC went from 0.72 (0.1) to 0.72 (0.1) (P = 0.50). Landmark survival analysis revealed that ΔD_LCO from 6 months after LVAD implantation was predictive of death for HF patients [hazard ratio (95% confidence interval), 0.60 (0.28-0.98); P = 0.03].

Conclusions: Pulmonary function did not improve after LVAD implantation. The degree of D_LCO deterioration is related to haemodynamic status post-LVAD implantation. The ΔD_LCO within 6 months post-operative was associated with survival.

Keywords: Continuous flow pumps; DLCO; Pulmonary circulation.