Lymphocytic choriomeningitis virus meningoencephalitis in a renal transplant recipient following exposure to mice

Abstract

Solid organ transplant recipients (SOTR) are at increased risk for a wide variety of typical and atypical infections as a consequence of impaired cell mediated and humoral immunity. We report a case of meningoencephalitis in a renal transplant recipient caused by lymphocytic choriomeningitis virus (LCMV) acquired by exposure to mice excreta. The clinical course was complicated by the development of hydrocephalus, requiring a ventriculoperitoneal shunt. To our knowledge, this is the first reported case of LCMV infection in a SOTR that was not organ donor derived.

Keywords: immunosuppression; lymphocytic choriomeningitis virus; meningoencephalitis; renal transplant recipient; rodents.