Validation of a robust strategy for proton spot scanning for oesophageal cancer in the presence of anatomical changes

Ditte Sloth Møller; Markus Alber; Marianne Nordsmark; Tine Bisballe Nyeng; Christina Maria Lutz; Lone Hoffmann

doi:10.1016/j.radonc.2018.09.018

Validation of a robust strategy for proton spot scanning for oesophageal cancer in the presence of anatomical changes

Radiother Oncol. 2019 Feb:131:174-178. doi: 10.1016/j.radonc.2018.09.018. Epub 2018 Oct 16.

Authors

Ditte Sloth Møller¹, Markus Alber², Marianne Nordsmark³, Tine Bisballe Nyeng⁴, Christina Maria Lutz⁴, Lone Hoffmann⁴

Affiliations

¹ Department of Medical Physics, Aarhus University Hospital, Denmark. Electronic address: dittmoel@rm.dk.
² Department of Radiation Oncology, Heidelberg University Hospital, Germany.
³ Department of Oncology, Aarhus University Hospital, Denmark.
⁴ Department of Medical Physics, Aarhus University Hospital, Denmark.

PMID: 30340776
DOI: 10.1016/j.radonc.2018.09.018

Abstract

SFUD strategies with one or two posterior proton beams and three target coverage strategies are compared with IMRT and tested for robustness towards anatomical changes by recalculation on surveillance CTs during treatment. We find posterior beam SFUD combining PTV coverage with robust optimization increases robustness towards anatomical changes compared to IMRT.

Keywords: Adaptation; Anatomical changes; Oesophageal cancer; Proton therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chemoradiotherapy
Esophageal Neoplasms / diagnostic imaging*
Esophageal Neoplasms / drug therapy
Esophageal Neoplasms / radiotherapy*
Humans
Proton Therapy / methods*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods*
Radiotherapy, Intensity-Modulated / methods
Tomography, X-Ray Computed / methods