Abstract
The cardiovascular effects of porins were evaluated using porins isolated from Salmonella typhimurium SH5014. In dogs porins depress arterial systemic pressure, vasomotor reactivity of norepinephrine and peripheral vagal stimulation. They are capable of modifying the sinocarotidal baroreceptor reactivity. In mice porins increase the cardiotoxic effects of isoprenaline, thyroxine, emetine and of p-nitrophenol. In rats porins increase the arrhythmogenic and lethal effects of BaCl2 and also give rise to renal lesions, probably at the tubular level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Outer Membrane Proteins / pharmacology*
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Barium / pharmacology
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Barium Compounds*
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Blood Pressure / drug effects*
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Cardiomyopathies / chemically induced
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Chlorides*
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Dogs
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Drug Synergism
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Electrocardiography
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Emetine / pharmacology
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Heart Rate / drug effects*
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Isoproterenol / pharmacology
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Kidney / drug effects*
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Male
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Mice
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Nitrophenols / pharmacology
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Porins
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Rats
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Respiration / drug effects
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Salmonella typhimurium*
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Thyroxine / pharmacology
Substances
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Bacterial Outer Membrane Proteins
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Barium Compounds
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Chlorides
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Nitrophenols
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Porins
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barium chloride
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Barium
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Isoproterenol
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Thyroxine
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Emetine
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4-nitrophenol