Design and synthesis of C 3-symmetric molecules bearing propellane moieties via cyclotrimerization and a ring-closing metathesis sequence

Abstract

We have developed an efficient synthetic strategy to assemble C ₃-symmetric molecules containing propellane moieties as end groups and a benzene ring as a central core. The synthesis of these C ₃-symmetric molecules involves simple starting materials. Our approach to C ₃-symmetric compounds relies on a Diels-Alder reaction, cyclotrimerization and ring-closing metathesis as key steps.

Keywords: Diels–Alder; cyclotrimerization; propellane; ring-closing metathesis.