Abstract
Pulmonary collision tumors have been described as a special entity of synchronous multiple lung cancer. There have been no reports detailing the chronological changes in primary collision lung cancers on chest computed tomography. We report a case of ground-glass lung nodules gradually colliding with each other. The collision tumors of the lung were composed of minimally invasive adenocarcinoma and adenocarcinoma in situ with epidermal growth factor mutations. Immunohistochemically, the Ki-67 labeling indices were different in the 2 components. Ki-67 staining was useful to distinguish the 2 components. The 2 dominant ground-glass tumors grew slowly with radiologic and pathologic heterogeneity.
Keywords:
Adenocarcinoma; Adenocarcinoma in situ; Ki-67 antigen; Lung neoplasms; Neoplasms; Receptor; epidermal growth factor; multiple primary.
MeSH terms
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Adenocarcinoma in Situ / chemistry
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Adenocarcinoma in Situ / diagnostic imaging*
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Adenocarcinoma in Situ / genetics
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Adenocarcinoma in Situ / pathology
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Adenocarcinoma of Lung / chemistry
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Adenocarcinoma of Lung / diagnostic imaging*
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Adenocarcinoma of Lung / pathology*
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DNA Mutational Analysis
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ErbB Receptors / genetics
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Female
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Humans
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Immunohistochemistry
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Ki-67 Antigen / analysis
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Lung Neoplasms / chemistry
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Lung Neoplasms / diagnostic imaging*
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Lung Neoplasms / genetics
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Lung Neoplasms / pathology*
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Lymph Node Excision
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Middle Aged
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Mutation
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Neoplasm Staging
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Neoplasms, Multiple Primary / chemistry
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Neoplasms, Multiple Primary / diagnostic imaging*
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / pathology*
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Pneumonectomy
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Predictive Value of Tests
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Tomography, X-Ray Computed*
Substances
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Ki-67 Antigen
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MKI67 protein, human
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EGFR protein, human
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ErbB Receptors