Vaccine strain Listeria monocytogenes bacteremia occurring 31 months after immunization

Infection. 2019 Jun;47(3):489-492. doi: 10.1007/s15010-018-1249-7. Epub 2018 Nov 14.

Abstract

Background: Listeria monocytogenes is a food-borne, facultative intracellular bacterium that causes severe diseases such as sepsis and meningoencephalitis in immunocompromised hosts. Because it stimulates robust T-lymphocyte-mediated responses, attenuated L. monocytogenes are candidate vaccine vectors for tumor immunotherapy.

Case: We report a case of bacteremia caused by vaccine strain L. monocytogenes (Axalimogene filolisbac) occurring 31 months after immunization against human papilloma virus (HPV) associated cervical cancer.

Conclusion: Receipt of a L. monocytogenes-based vaccine is a novel risk factor for delayed L. monocytogenes bacteremia.

Keywords: Immunotherapy; Live vaccine; Recurrent listeriosis. Listeria vaccine.

Publication types

  • Case Reports

MeSH terms

  • Bacteremia / diagnosis*
  • Bacteremia / microbiology
  • Bacterial Vaccines
  • Fatal Outcome
  • Female
  • Humans
  • Immunization
  • Listeria monocytogenes / isolation & purification*
  • Listeriosis / diagnosis*
  • Listeriosis / microbiology
  • Middle Aged
  • Oklahoma
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Infections / virology
  • Time Factors
  • Uterine Cervical Neoplasms / prevention & control*
  • Uterine Cervical Neoplasms / virology

Substances

  • Bacterial Vaccines