Chitosan as a stabilizer and size-control agent for synthesis of porous flower-shaped palladium nanoparticles and their applications on photo-based therapies

Thi Tuong Vy Phan; Giang Hoang; Van Tu Nguyen; Thanh Phuoc Nguyen; Hye Hyun Kim; Sudip Mondal; Panchanathan Manivasagan; Madhappan Santha Moorthy; Kang Dae Lee; Oh Junghwan

doi:10.1016/j.carbpol.2018.10.062

Chitosan as a stabilizer and size-control agent for synthesis of porous flower-shaped palladium nanoparticles and their applications on photo-based therapies

Carbohydr Polym. 2019 Feb 1:205:340-352. doi: 10.1016/j.carbpol.2018.10.062. Epub 2018 Oct 28.

Affiliations

¹ Interdisciplinary Program of Biomedical Mechanical & Electrical Engineering, Pukyong National University, Busan, 48513, Republic of Korea; Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan, 48513, Republic of Korea.
² Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan, 48513, Republic of Korea.
³ Department of Otolaryngology-Head and Neck Surgery, Kosin University, College of Medicine, Busan 48513, Republic of Korea.
⁴ Interdisciplinary Program of Biomedical Mechanical & Electrical Engineering, Pukyong National University, Busan, 48513, Republic of Korea; Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan, 48513, Republic of Korea; Department of Biomedical Engineering, Pukyong National University, Busan, 48513, Korea Republic of Korea. Electronic address: jungoh@pknu.ac.kr.

PMID: 30446113
DOI: 10.1016/j.carbpol.2018.10.062

Abstract

This study reported a newly developed green synthesis method using chitosan and vitamin C to prepare porous flower-shaped palladium nanoparticles. We found that chitosan not only worked as a stabilizer but also as a size-control agent for the synthesis of these nanoparticles. The growth model of flower-shaped palladium nanoparticles was proposed to interpret mechanistic understanding. The obtained nanoparticles showed good biocompatibility and strong near-infrared absorption. The nanoparticles were successfully demonstrated to be highly efficient for both in vitro photothermal therapy and in vitro photoacoustic imaging.

Keywords: Chitosan; Flower-shaped palladium nanoparticles; Green synthesis; Photoacoustic imaging; Photothermal therapy.