Metformin inhibits prostate cancer growth induced by a high-fat diet in Pten-deficient model mice

Int J Urol. 2019 Feb;26(2):307-309. doi: 10.1111/iju.13847. Epub 2018 Nov 20.
No abstract available

Keywords: high-fat diet; metformin; model mice; prostate cancer.

MeSH terms

  • Animals
  • Diet, High-Fat / adverse effects*
  • Disease Progression
  • Male
  • Metformin / pharmacology*
  • Metformin / therapeutic use
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Myeloid-Derived Suppressor Cells / drug effects
  • Myeloid-Derived Suppressor Cells / immunology
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / etiology
  • Neoplasms, Experimental / pathology
  • PTEN Phosphohydrolase / deficiency*
  • PTEN Phosphohydrolase / genetics
  • Prostate / cytology
  • Prostate / drug effects
  • Prostate / immunology
  • Prostate / pathology
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / etiology
  • Prostatic Neoplasms / pathology
  • Prostatitis / drug therapy*
  • Prostatitis / etiology
  • Prostatitis / pathology
  • Treatment Outcome

Substances

  • Metformin
  • PTEN Phosphohydrolase
  • Pten protein, mouse