Clinical metric for differentiating intracranial hemangiopericytomas from meningiomas using diffusion weighted MRI

Clin Imaging. 2019 Mar-Apr:54:1-5. doi: 10.1016/j.clinimag.2018.10.018. Epub 2018 Nov 1.

Abstract

Purpose: Intracranial Hemangiopericytomas (IHP) are dural based tumors that frequently recur/metastasize. Unfortunately, their imaging appearance overlaps significantly with more benign meningiomas. We evaluated the use of diffusion weighted imaging (DWI) to differentiate IHP from meningioma.

Methods: We compared MRI of IHP tumors (WHO Grades II/III) (n = 20) to meningioma (n = 48, WHO Grade I/II).

Findings: ADC values differed between IHP (1.05 × 10-3 mm2/s) and meningiomas (0.89 × 10-3 mm2/s) (p = 0.05). Normalized ADC ratios (nADC), differed between IHP and meningiomas (1.30 vs 1.07, p = 0.03).

Conclusion: Importantly, a nADC cutoff of >1.3 was specific (96%) but not sensitive (35%) for identifying IHP.

Keywords: Brain tumor; Diffusion weighted imaging; Intracranial hemangiopericytoma; MRI; Meningioma.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology
  • Diagnosis, Differential
  • Diffusion Magnetic Resonance Imaging / methods*
  • Female
  • Hemangiopericytoma / diagnosis*
  • Hemangiopericytoma / diagnostic imaging
  • Hemangiopericytoma / pathology
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Meningeal Neoplasms / diagnosis*
  • Meningeal Neoplasms / diagnostic imaging
  • Meningeal Neoplasms / pathology
  • Meningioma / diagnosis*
  • Meningioma / diagnostic imaging
  • Meningioma / pathology
  • Middle Aged
  • Sensitivity and Specificity
  • Young Adult