Abstract
A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate, enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.
MeSH terms
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Animals
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Cardiotonic Agents / chemical synthesis
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Cardiotonic Agents / therapeutic use*
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / therapeutic use
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Hydrazines / chemical synthesis
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Hydrazines / therapeutic use
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Male
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Mitochondria / metabolism*
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Myocardial Reperfusion Injury / drug therapy*
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Myocardium / metabolism
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Nitric Oxide / metabolism
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Nitric Oxide Donors / chemical synthesis
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Nitric Oxide Donors / therapeutic use*
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Phosphinic Acids / chemical synthesis
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Phosphinic Acids / therapeutic use
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Rats, Wistar
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Superoxides / chemistry*
Substances
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Cardiotonic Agents
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Free Radical Scavengers
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Hydrazines
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Nitric Oxide Donors
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Phosphinic Acids
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Superoxides
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Nitric Oxide